Toward Lead-Oriented Synthesis: One-Pot Version of Castagnoli Condensation with Nonactivated Alicyclic Anhydrides

Мова статті: 
Англійська
Автор(и) статті: 
Ryabukhin, S.V., Panov, D.M., Granat, D.S., Ostapchuk, E.N., Kryvoruchko, D.V., Grygorenko, O.O
Вихідні данні статті: 
ACS Combinatorial Science 2014, 16, 146−153.
Назва журналу: 
ACS Combinatorial Science
Рік публікації: 
2014
Volume: 
16
Ключові слова: 
multicomponent reaction; condensation; anhydride; aldehyde; amine; lead-oriented synthesis
Ключове слово: 
multicomponent reaction
Ключове слово: 
condensation
Ключове слово: 
anhydride
Ключове слово: 
lead-oriented synthesis
Impact Factor: 
3,401
One-pot variation of Castagnoli condensation, that is, reaction of cyclic anhydrides, amines, and aldehydes, has been developed as a combinatorial approach to 1,2-disubstituted 5-oxopyrrolidine- and 6-oxopiperidine-3-carboxylic acids, as well as their benzo-analogues. Utility of the method to multigram preparation of building blocks and synthetic intermediates was also demonstrated. The final products are obtained in high yields and diastereoselectivity. The method fits well in the concept of lead-oriented synthesis; in particular, it can be used for the design of lead-like compound libraries, even if the strictest cut-offs are applied to the physicochemical properties of their members.
Назва підрозділу: 
Кафедра супрамолекулярної хімії та біохімії
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Дизайн: Інститут високих технологій
Ivan Ivanov