Impact of cell division on intracellular uptake and nuclear targeting with fluorescent SiC-based nanoparticles

Мова статті: 
Англійська
Автор(и) статті: 
Tetiana Serdiuk, Vladimir Lysenko, Barbara Mognetti, Valery Skryshevsky, Alain Géloën
Вихідні данні статті: 
Journal of Biophotonics Volume 6, Issue 3, pages 291–297, March 2013
Назва журналу: 
Journal of Biophotonics
Рік публікації: 
2013
Volume: 
6
Issue: 
3
Ключові слова: 
cell proliferation, nanoparticles, silicon carbide, fluorescence
Ключове слово: 
cell proliferation
Ключове слово: 
nanoparticles
Ключове слово: 
silicon carbide
Ключове слово: 
fluorescence
Semiconductor nanoparticles (NPs) became important and wide-used tool for cell imaging because of their unique remarkable properties. Nevertheless, all previous investigations in this area were done on proliferating cells. For the first time, this work demonstrates strong influence of cell active proliferation/contact inhibition of proliferation on uptake of NPs. In addition, we show that cell division plays key-role in penetration of silicon carbide based NPs (SiC NPs) inside the cell nucleus. This may very likely concern other types of NPs able to reach the cell nuclei. In particular, observed effect of cell division gives perspectives for future selective cancer treatment with NPs.
Назва підрозділу: 
Кафедра нанофізики конденсованих середовищ
ІНСТИТУТ ВИСОКИХ ТЕХНОЛОГІЙ Матеріали дозволено використовувати на умовах GNU FDL без незмінюваних секцій та Creative Commons Attribution/Share-Alike
Дизайн: Інститут високих технологій
Ivan Ivanov