Controlling Biological Activity with Light: Diarylethene-Containing Cyclic Peptidomimetics
Мова статті:
Англійська
Вихідні данні статті:
Angewandte Chemie International Edition Volume 53, Issue 13, pages 3392–3395, March 24, 2014
Назва журналу:
Angewandte Chemie International Edition
Рік публікації:
2014
Volume:
53
Issue:
13
Ключові слова:
antimicrobial agents;diarylethenes;gramicidin S;peptidomimetics;photochemistry
Ключове слово:
antimicrobial agents
Ключове слово:
diarylethenes
Ключове слово:
gramicidin S
Ключове слово:
peptidomimetics
Ключове слово:
photochemistry
Посилання на статтю:
http://onlinelibrary.wiley.com/doi/10.1002/anie.201310019/abstract
Impact Factor:
13,734 Photobiological processes in nature are usually triggered by nonpeptidic chromophores or by modified side chains. A system is presented in which the polypeptide backbone itself can be conformationally switched by light. An amino acid analogue was designed and synthesized based on a reversibly photoisomerizable diarylethene scaffold. This analogue was incorporated into the cyclic backbone of the antimicrobial peptide gramicidin S at several sites. The biological activity of the resulting peptidomimetics could then be effectively controlled by ultraviolet/visible light within strictly defined spatial and temporal limits.
Назва підрозділу:
Кафедра супрамолекулярної хімії та біохімії